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Previously, Charles served as the coordinator for bioinformatics for the California State Water Board and lead scientist for short-lived climate pollutants within the executive office of the California Department of Food and Agriculture, where he created and managed the first U.S. state program to support enteric methane research. He is also an affiliate researcher of the Systems Microbiology and Natural Products Laboratory at the University of California, Davis, where he focuses on evaluating strategies to reduce livestock enteric methane, rumen microbiome responses, and the discovery of novel microbial compounds.